Publications
Recommended Publications
Tai, L.M., Maldonado Weng, J., LaDu, M.J., and Brady, S.T. Relevance of transgenic mouse models for Alzheimer's disease. Progress in Molecular Biology and Translational Science. 2020 Aug. doi: 10.1016/bs.pmbts.2020.07.007.
Lewandowski, C.T., Maldonado Weng, J., and M.J. LaDu. Alzheimer's disease pathology in ApoE transgenic mouse models: The Who, What, When, Where, Why, and How. Neurobiology of Disease. 2020 Feb. doi: 10.1016/j.nbd.2020.104811.
Maldonado Weng, J., Parikh, I., Naqib, A., York, J., Green, S.J., Estus, S., and M.J. LaDu. Synergistic effects of APOE and sex on the gut microbiome of young EFAD transgenic mice. Molecular Neurodegeneration. 2019 Dec 20;14(1):47. doi: 10.1186/s13024-019-0352-2. PMID: 31861986.
Balu, D., Karstens, A.J., Loukenas, E., Maldonado Weng, J., York, J., Valencia-Olvera, A.C., and M.J. LaDu. The role of APOE in transgenic mouse models of AD. Neuroscience Letters. 2019 Aug 10;707:134285. doi: 10.1016/j.neulet.2019.134285. PMID: 31150730.
Tai, L.M., Balu, D., Avila-Munoz, E., Abdullah, L., Thomas, R., Collins, N., Valencia-Olvera, A.C., and M.J. LaDu. EFAD Transgenic Mice as a Human APOE Relevant Preclinical Model of Alzheimer's Disease. Journal Lipid Research. 2017 April 7. pii: jlr.R076315. doi: 10.1194/jlr.R076315. PMID: 28389477.
Koster, K.P., Smith, C., Valencia-Olvera, A.C., Thatcher, G.R.J., Tai, L.M., and M.J. LaDu. Rexinoids as Therapeutics for Alzheimer's Disease: Role of APOE. Current Topics in Medicinal Chemistry. 2017; 17(6):708-720. doi: 10.2174/1568026616666160617090227. PMID: 27320328.
Tai L.M., Ghura S., Koster K.P., Liakaite V., Maienschein-Cline M., Kanabar P., Collins N., Ben-Aissa M., Lei AZ., Bahroos N., Green S.J., Hendrickson B., Van Eldik L.J., and M.J. LaDu. APOE modulated Aβ-induced neuroinflammation in Alzheimer's disease: current landscape, novel data and future perspective. Journal of Neurochemistry. 2015 May 13. doi: 10.1111/jnc.13072. PMID: 25689586. PMCID: PMC4400246.
Tai, L.M., Mehra, S., Estus, S., Rebeck, G.W., Bu, G., and M.J. LaDu. Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk. Molecular Neurodegeneration. 9(1):2. doi: 10.1186/1750-1326-9-2, 2014. PMID: 24386905. PMCID: PMC3897976.
Tai, L.M., Koster, K.P., Luo, J., Lee, S.H., Wang, Y-T, Collins, N.C., Ben Aissa, M., Thatcher, G.R.J., and M.J. LaDu. Amyloid-β pathology and APOE genotype modulate retinoid x receptor agonist activity in vivo. Journal of Biological Chemistry. 2014. Epub 2014/09/14. doi: 10.1074/jbc.M114.600833. PMID: 25217640. PMCID: PMC4215234.
Tai, L.M., Bilousova, T., Jungbauer, L., Roeske, S., Youmans, K.L., Chungjiang, Y., Poon, W.W., Cornwell, L.B., Miller, C.A., Vinters, H.V., Van Eldik, L.J., Fardo, D.W., Estus, S., Bu, G., Gylys, K.H., and M.J. LaDu. Levels of Soluble Apolipoprotein E/Amyloid-B(AB) Complex Are Reduced and Oligomeric AB Increased with APOE4 and Alzheimer Disease in a Transgenic Mouse Model and Human Samples. The Journal of Biological Chemistry. 2013. doi: 10.1074/jbcM112.442103, PMID: 23293020, PMCID: PMC3581407.
Youmans, K.L., Tai, L.M., Nwabuisi-Heath, E., Jungbauer, L.M., Kanekiyo, T., Gan, M., Kim, W., Eimer, W.A., Estus, S., Rebeck, G.W., Weeber, E., Bu, G., Yu, C., and M.J. LaDu. APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer's disease. Journal of Biological Chemistry. 2012. PMID: 23060451, PMCID: PMC3516726.
Tai, L.M., Youmans, K., Stine, W.B., Michon S.C., Kanekiyo, T., Manelli, A.M., Fu, Y., Eimer, W.A., Bu, G., Binder, L., Yu, C., Hartley, D.M., and M.J. LaDu. Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody. Molecular Neurodegeneration. 7(8), doi:10.1186/1750-1326-7-8, 2012. PMID: 22423893, PMCID: PMC3355009.
Youmans, K., Leung, S., Zhang, J., Maus, E., Baysac, K., Bu, G., Vassar, R., Yu, C., and M.J. LaDu. Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations. Journal of Neuroscience Methods. 2011 Mar 15;196(1):51-9. doi: 10.1016/j.jneumeth.2010.12.025. PMID: 21219931, PMCID: PMC3049315.
Tai, L.M., Youmans, K.L., Jungbauer, L.M., Yu, C.J., and M.J. LaDu. Introducing human APOE into Aβ transgenic mouse models. International Journal of Alzheimer's Disease. doi:10.4061/2011/810981, 2011. PMID: 22028984, PMCID: PMC3199079.
Yu, C., Youmans, K.L., and M.J. LaDu. Proposed mechanism for lipoprotein remodeling in the brain. Biochem. Biophys. Acta. 2010 Aug;1801(8):819-23. doi: 10.1016/j.bbalip.2010.05.001. PMID: 20470897, PMCID: PMC3253707.