Books / Chapters

Journal Publications

Tai LM, Balu D, Avila-Munoz E, Abdullah L, Thomas R, Collins N, Valencia-Olvera AC, LaDu M.J.. EFAD Transgenic Mice as a Human APOE Relevant Preclinical Model of Alzheimer's Disease. Journal Lipid Research. 2017 April 7. pii: jlr.R076315. doi: 10.1194/jlr.R076315. PMID: 28389477.

Abdullah L, Evans JE, Emmerich T, Crynen G, Shackleton B, Keegan AP, Luis C, Tai L, LaDu M.J., Mullan M, Crawford F, Bachmeier C. APOE ε4 specific imbalance of arachidonic acid and docosahexaenoic acid in serum phospholipids identifies individuals with preclinical Mild Cognitive Impairment/Alzheimer's Disease. Aging. 2017 March 23;9(3):964-985. doi: 10.18632/aging.101203. PMID: 28333036. PMCID: PMC5391242.

Teter, B., LaDu MJ, Sullivan, P.M., Frautschy, S.A., and G.M. Cole. Apolipoprotein E Isotype-dependent Modulation of microRNA-146a in plasma and brain. NeuroReport. 2016. 27(11):791-5. PMID: 27281274. PMCID: PMC5042345.

Ghura, S., Tai, L.M., Zhao, M., Collins, N.C., Che, C-T., and K.M. Warpeha, K.M., and LaDu M.J.. Arabidopsis thaliana extracts optimized for polyphenols production as potential therapeutics for the APOE-modulated neuroinflammation characteristic of Alzheimer’s disease in vitro. cientific Reports. 2016. 6, 29364; doi: 10.1038/srep29364. PMID: 27383500. PMCID: 4935988.

Koster, K.P., Smith, C., Valencia-Olvera, A.C., Thatcher, G.R.J., Tai, L.M., and LaDu M.J.. Rexinoids as therapeutics for Alzheimer disease: Role of APOE. urrent Topics in Medicinal Chemistry. 2016, Vol. 16, No. 30. PMID: 27320328.

Zhou. M., Huang, T., Collins, N.C., Zhang, J., Shen, H., Dai, X., Xiao, N., Wu, X., Wei, Z., York, J., Lin, L., Zhu, Y., LaDu M.J., and X Chen. APOE4 induces site-specific tau phosphorylation through calpain-CDK5 signaling pathway in EFAD-Tg mice. Current Alzheimer Research. 2016. PMID: 27087442.

Luo, J., Lee, S.H., VandeVrede, L., Qin, Z., BenAissa, M., Larson, J., Teich, A.F., Arancio, O., D’Souza, Y., Elharram, A., Koster, K., Tai, L.M., LaDu M.J., Bennett, B. and G.R.J. Thatcher. A multifunctional therapeutic approach to disease modification in multiple mouse models of Alzheimer's disease. Molecular Neurodegeneration. 2016. April 29. doi: 10.1186/s13024-016-0103-6. PMID: 27129593. PMCID: PMC4850651.

Cacciottolo, M., Christensen, A., Moser, A., Liu, J., Pike, C.J., Smith, C., LaDu M.J., Sullivan, P.M., Morgan, T.E., Dolzhenko, E., Charidimou, A., Wahlund, L.-O., Wiberg, M.K., Shams, S., Chiang, G.C.-Y., and C.E. Finch. The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer’s Disease of humans and mice. Neurobiology of Aging. 2016. 37:47-57. doi: 10.1016/j.neurobiolaging. 2015.10.010. PMID: 26686669. PMCID: PMC4687024.

Malik, M., Parikh, I., Vasquez, J.B., Smith, C., Tai, L.M., Bu, G., LaDu M.J., Fardo, D.W., Rebeck, G.W., and S. Estus. Genetics ignite focus on microglial inflammation in Alzheimer’s disease. Molecular Neurodegeneration. 2015 October 5. doi 10.1186/s13024-015-0048-1. PMID: 26438529. PMCID: PMC4595327.

Liu, D-s., Pan,, X-d., Zhang, J., Shen, H., Collins, N.C., Cole, A., Dai, X-m., Zhou, M., Tai, L.M., Ben Aissa, M., Zhu, Y-g., LaDu, M.J. and X-c. Chen. APOE4 reduces cognitive function by down-regulating NMDA receptor pathway in EFAD-Tg mice. Molecular Neurodegeneration. 2015 March 05. doi:10.1186/s13024-015-0002-2. PMCID: PMC4391134.

Tai, L., Ghura, S., Koster, K., Liakaite, V., Maienschein-Cline, M., Kanabar, P., Collins, N., Ben-Aissa, M., Zhengdeng Lei, A., Bahroos, N., Green. S., Hendrickson, W., Van Eldik. L.J., and M.J. LaDu. APOE modulated Aβ-induced neuroinflammation in Alzheimer's disease: current landscape, novel data and future perspective. Invited review Journal of Neurochemistry. 2015 Feb 17. doi: 10.1111/jnc.13072. [Epub ahead of print] PMID: 25689586.

Tai, L.M., Koster, K.P., Luo, J., Lee, S.H., Wang, Y-T, Collins, N.C., Ben Aissa, M., Thatcher, G.R.J., and M.J. LaDu. Amyloid-β pathology and APOE genotype modulate retinoid x receptor agonist activity in vivo. Journal of Biological Chemistry, doi: 10.1074/jbc.M114.600833. 2014. Epub 2014/09/14. PMID: 25217640. PMCID: PMC4215234.

Rodriguez G.A., Tai, L.M., LaDu, M.J. and G. W. Rebeck. Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition. Journal of Neuroinflammation, doi:10.1186/1742-2094-11-111, 2014. PMID:24948358. PMCID:PMC4077554.

Gold, B.T., Zhu, Z., Brown, C., Andersen, A.H., LaDu, M.J, Tai, L.M, Jicha G.A., Kryscio R.J., Estus, S. Nelson, P.T., Scheff, S.W., Schmitt, E.A.F.A, L.J., Van Eldik and C.D. Smith. White matter integrity is associated with CSF markers of AD in normal adults. Neurobiology of Aging, 10.1016 j.neurobiolaging.2014.04.03, 2014.PMID: 24866404. PMCID: PMC4087077.

Nwabuisi-Heath, E., Rebeck, G.W., LaDu. M.J., and C. Yu. ApoE4 delays dendritic spine formation during neuron development and accelerates loss of mature spines in vitro. ASN-NEURO, doi:10.1042/AN20130043, 2014. PMID: 24328732. PMCID: PMC3891498.

Tai, L.M., Mehra, S., Estus, S., Rebeck, G.W., Bu, G., and M.J. LaDu. Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk. Molecular Neurodegeneration, 9(1):2. doi: 10.1186/1750-1326-9-2, 2014. PMID: 24386905. PMCID: PMC3897976.

Kunzler, J., Youmans, K., Yu, C., LaDu. M.J., and L. Tai. APOE modulates the effect of estrogen replacement therapy on Aβ accumulation EFAD-Tg mice. Neuroscience Letters, 560:131-6, 2013. PMID: 24368217.

Zhao, W., Dumanis, S., Tamboli, I., Rodriguez, G., LaDu, M.J., Moussa, C., and G.W. Rebeck. Human APOE Genotype Affects Intraneuronal Aβ1-42 Accumulation in a Lentiviral Gene Transfer Model. Human Molecular Genetics, 23(5):1365-1375. doi:10.1093/hmg/ddt525, 2013. PMID: 24154541.

Wolf, A.B., Valla, J., Bu, G., Kim, J., LaDu, M.J., Reiman, E.M., and R.J. Caselli. Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease. Alzheimer's Research and Therapy, 5(5):38, 2013. PMID:23998393.

Tai, L.M., Bilousova, T., Jungbauer, L., Roeske, S.K., Yu, C., Estus, S., Bu, G., Van Eldik, L., Gylys, K., and M.J. LaDu. Soluble apolipoprotein E/amyloid-β (apoE/Aβ) complex levels are reduced in Alzheimer's disease patients and further with APOE4 in AD transgenic mice and human samples. Journal of Biological Chemistry. In press, Paper of the Week, January 11, 2013. PMID: 23293020 PMCID: PMC3581407

Li, J., Kanekiyo, T., Shinohara, M., Zhang, Y., LaDu, M.J., Xu, H., and G. Bu. Differential Regulation of Amyloid-β Endocytic Trafficking and Lysosomal Degradation by Apolipoprotein E Isoforms. Journal of Biological Chemistry. Paper of the Week, Decemeber 28, 2012. PMID: 231328582012, PMCID: PMC3531774.

Youmans, K.L., Tai, L.M., Nwabuisi-Heath, E., Jungbauer, L.M., Kanekiyo, T., Gan, M., Kim, W., Eimer, W.A., Estus, S., Rebeck, G.W., Weeber, E., Bu, G., Yu, C., and M.J. LaDu. APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer's disease. Journal of Biological Chemistry. 2012. PMID: 23060451, PMCID: PMC3516726.

Nwabuisi-Heath, E., LaDu, M.J. and C. Yu. Simultaneous analysis of dendritic spine density, morphology and glutamate receptors during neuron maturation in vitro by quantitative immunocytochemistry. Journal of Neuroscience Methods, doi:10.1016/j.jneumeth.2012.04.03, 2012. PMID: 22521963, PMCID: PMC3367123.

Tai, L.M., Youmans, K., Stine, W.B., Michon S.C., Kanekiyo, T., Manelli, A.M., Fu, Y., Eimer, W.A., Bu, G., Binder, L., Yu, C., Hartley, D.M., and M.J. LaDu. Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody. Molecular Neurodegeneration, 7(8), doi:10.1186/1750-1326-7-8, 2012. PMID: 22423893, PMCID: PMC3355009.

Zhu, Y., Nwabuisi-Heath, E., Dumanis S.B, Tai, L., Yu, C., Rebeck, G.W, and M.J. LaDu. ApoE genotype alters glial-mediated neuroinflammation and synaptotoxicity in mice. Glia, 60(4):559-69, 2012. PMID:22228589. PMCID:PMC3276698

LaDu M.J., Munson, G. S., Jungbauer, L.M., Getz, G. S., Reardon, C.A., Tai, L.M., and C. Yu. Preferential interactions between apoE-containing lipoproteins and Aβ revealed by a detection method that combines SEC fractionation with stringent analysis. BBA-Molecular and Cell Biology of Lipids, 1821(2):295-302, 2012. PMID:22138302. PMCID: PMC3273043.

Tai, L.M., Youmans, K.L., Jungbauer, L.M., Yu, C.J., and M.J. LaDu. Introducing human APOE into Aβ transgenic mouse models. International Journal of Alzheimer's Disease, doi:10.4061/2011/810981, 2011. PMID: 22028984, PMCID: PMC3199079.

Park, S.K., Pegan, S.D., Mesecar, A.D., Jungbauer, L.M., LaDu, M.J., and S.W. Liebman. Development and validation of a yeast high-throughput screen for inhibitors of Aβ42 oligomerization. Disease Models and Mechanisms, 4(6):822-31, 2011. PMID: 21810907, PMCID: PMC3209651.

Youmans, K., Leung, S., Zhang, J., Maus, E., Baysac, K., Bu, G., Vassar, R., Yu, C., and M.J. LaDu. Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations. Journal of Neuroscience Methods, 196(1):51-59, 2011. PMID: 21219931, PMCID: PMC3049315.

Reed, M., Hofmeister, J., Jungbauer, L., Welzel, A., Yu, C.J., Sherman, M., Lesne, S., LaDu, M.J., Walsh, D., Ashe, K., and J.P. Cleary. Cognitive effects of cell-derived naturally and synthetically derived Aβ42. Neurobiology of Aging, 32(10):1784-94, 2011. PMID: 20031278, PMCID: PMC2895944.

Lewis, T., Cao, D., Lu, H., Mans, R., Su, YR, Linton, MF, Fazio, S., LaDu, MJ, and Ling Li. Over-expression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer's disease. J. Biol. Chem. 285(47): 36958–36968, 2010. PMID: 20847045, PMCID: PMC2978624.

Fuentealba, R., Zhang, J., Liu, Q., Kanekiyo, T., Hu, X., Lee, J., LaDu. M.J., and G. Bu. Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Aβ42 uptake and lysosomal accumulation. PLoS ONE 5(7): e11884. doi:10.1371/journal.pone.0011884, 2010. PMID:20686698, PMCID: PMC2912373.

Yu, C., Youmans, K., and M.J. LaDu. Proposed mechanism for lipoprotein remodeling in the brain. Biochem. Biophys. Acta, 1801:819-23, 2010. PMID:20470897, NIHMSID: NIHMS206446.

Yu, C., Laxton, K., Heath, E., and M.J. LaDu. Endocytic pathways mediating oligomeric Aβ42 neurotoxicity. Molecular Neurodegeneration, 5(19), 2010. PMID:20478062, PMCID: PMC2881055.

Dumanis, S., Tesoriero, J., Babus, L., Nguyen, T., Trotter, J., LaDu, M.J., Weeber, E., Turner, R., Xu, B., Rebeck, W., and H.S. Hoe. APOE4 decreases spine density and dendritic complexity in cortical neurons in vivo. Journal of Neuroscience, 29(48):15317-22, 2009. PMID: 19955384, PMCID: PMC2846754.

Jungbauer, L.M., Yu, C.J, Laxton, K.J., and M.J. LaDu. Preparation of fluorescently-labeled amyloid-beta peptide assemblies: the effect of fluorophore conjugation on structure and function. Journal of Molecular Recognition, 22(5):403-13, 2009. PMID: 19343729, PMCID: PMC2827260.

Korwek, K., Trotter, J., LaDu, M.J., Sullivan, P., and E.J. Weeber. ApoE isoform-dependent changes in hippocampal synaptic function. Molecular Neurodegeneration, 4:21, 2009. PMID:19725929, PMCID: PMC2695436.

Pigino, G., Morfini, G., Atagi, Y., Deshpande, A., Yu, C.J., Jungbauer L., LaDu, M.J., Busciglio, J., and S.T. Brady. Pathogenic mechanism for intraneuronal amyloid beta: Disruption of fast axonal transport. PNAS, 106 (14): 5907-12, 2009. PMID:19321417, PMCID: PMC2667037.

Manelli AM, Bulfinch L, Sullivan PM, and MJ LaDu. Effect of Aβ structure and human apoE isoform on primary co-cultures of neurons and glia. Neurobiol. of Aging. 28:1139-1147, 2007.
  abstract | pdf

Yun SY, Gamkredlidze G, Stine B, Sullivan PM, Pasternak JF, LaDu MJ, and B Trommer. Amyloid-β-42 reduces neuronal excitability in mouse dentate gyrus. Neuroscience Letters. 403(1-2):162-165 2006.
  abstract | pdf

LaDu MJ, Stine WB, Narita M, Getz GS, Reardon CA, and G Bu. Self-assembly of HEK cell-secreted apoE particles resemble apoE-enrichment of lipoproteins as a ligand for the LDL receptor-related protein. Biochemistry. 45:381-390, 2006.
  abstract | pdf

Rebeck, G.W., LaDu M.J., Estus, S., Bu, G., and E.J. Weeber. The generation and function of soluble apoE receptors in the CNS. Mol. Neurodegener. 1:1-13, 2006.
  abstract | pdf

Yun SH, Park KA, Sullivan P, Pasternak JF, LaDu MJ, and BL Trommer. ACh receptors supress hippocampal LTP in wild type but not apoE4 targeted replacement mice . J. Neurosci. Res. 82(6):771-777, 2005.
  abstract | pdf

Chen S, Averett NT, Manelli AM, LaDu MJ, May W, and MD Ard. Isoform-specific effects of apolipoprotein E on secretion of inflammatory mediators in adult rat microglia . J. of Alzheimer's Disease. 7(1):25-35, 2005.
  abstract | pdf

White JA, Manelli AM, Holmberg KH, Van Eldik LJ, and MJ LaDu. Differential effects of oligomeric and fibrillar amyloid-β1-42 on glia-mediated inflammation. Neurobiol. Dis. 18(3):459-465, 2005.
  abstract | pdf

Trommer BL, Shah C, Gamkrelidze G, Yun SH, Pasternak ES, Stine B, Manelli A, Sullivan P, Pasternak JF, and MJ LaDu. Apolipoprotein E isoform-specific effects on LTP: blockade by oligomeric amyloid-β. Neurobiol. Dis. 18(1):75-82, 2005.
  abstract | pdf

Trommer BL, Shah C, Gamkrelidze G, Yun SH, Pasternak ES, Ye G, Sotak M, Sullivan P, Pasternak JF, and MJ LaDu. Apolipoprotein E isoform affects LTP in human targeted-replacement mice. Neuroreport. 15 (17):2655-2658, 2004.
  abstract | pdf

Irizarry M, Deng A, Lleo A, Berezovska O, von Armin C, Martin-Rehrmann M, Manelli A, LaDu MJ , Hyman B, and GW Rebeck E.S. Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein. J. Neurochem. 23:235-246, 2004.
  abstract | pdf

Guo L, LaDu MJ, and LJ Van Eldik. A dual role for apolipoprotein E in neuroinflammation: anti- and pro-inflammatory activity. J. Mol. Neuroscience. 23:203-210, 2004.
  abstract | pdf

Manelli AM, Stine Jr., Van Eldik LJ, and MJ LaDu. ApoE and Aβ1-42 interactions: effects of isoform and conformation on structure and function. J. Mol. Neurosci. 23(3):235-46, Review, 2004.
  abstract | pdf

Stine Jr., Dahlgren KD, Krafft GA, and MJ LaDu. In vitro characterization of conditions for amyloid-β peptide oligomerization and fibrillogenesis. J. Biol. Chem. 278(13):11612-22, 2003.
  abstract | pdf

Dahlgren KD, Manelli AM, Stine Jr. WB, Baker LK, Krafft GA, and MJ LaDu. Oligomeric and fibrillar species of amyloid-β peptides differentially affect neuronal viability. J. Biol. Chem. 277(35):32046-53, 2002.
  abstract | pdf

Narita M, Holtzman DM, Fagan AM, LaDu MJ, Yu L, Han X, Gross RW, Bu G, and AL Schwartz. Cellular catabolism of lipid poor apolipoprotein E via cell surface LDL receptor-related protein. J. Biochem. 132:743-749, 2002.
  abstract | pdf

Bentley NB, LaDu MJ, Rajan C, Getz GS, and CA Reardon. ApoE structural requirements for SDS-stable complex formation with β-amyloid (1-40). Biochemical J. 366:273-279, 2002.
  abstract | pdf

LaDu MJ, Shah JA, Reardon CA, Getz GS, Bu G, Hu J, Guo L, and LJ van Eldik. Apolipoprotein E and apolipoprotein E receptors modulate Aβ-induced glial neuroinflammatory responses. Neurochem. Int. 39(5-6):427-34, Review, 2001.
  abstract | pdf

Munson GW, Roher AE, Kuo YM, Gilligan SM, Reardon CA, Getz GS, and MJ LaDu. SDS-stable complex formation between native apolipoprotein E3 and β-amyloid peptides. Biochemistry 26;39(51):16119-24, 2000.
  abstract | pdf

LaDu MJ, Shah JA, Reardon CA, Getz GS, Bu G, Hu J, Guo L, and LJ van Eldik. Apolipoprotein E receptors mediate the effects of β-amyloid on astrocyte cultures. J. Biol. Chem. 27;275(43):33974-80, 2000.
  abstract | pdf

Tokuda T, Calero M, Matsubara E, Vidal R, Kumar A, Permanne B, Zlokovic B, Smith J, LaDu MJ, Rostagno A, Frangione B, and J Ghiso. Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid β-peptide. Biochem. J. 348:359-365, Review, 2000.
  abstract | pdf

Fagan AM, Holtzman DM, Munson G, Mathur T, Schneider D, Chang LK, Getz GS, Reardon CA, Lukens J, Shah JA, and MJ LaDu. Unique lipoproteins secreted by primary astrocytes from wild type, apoE null and human apoE transgenic mice. J. Biol. Chem. 15;274(42):30001-7, 1999.
  abstract | pdf

Hu J, LaDu MJ, and LJ Van Eldik. Apolipoprotein E attenuates β-amyloid astrocyte activation. J. Neurochem. 71:1626-1634, 1998.
  abstract | pdf

LaDu MJ, Gilligan S, Lukens JR, Cabana V, Reardon CA, Van Eldik LJ, and DM Holtzman. CSF lipoproteins differ from nascent astrocyte particles. J. Neurochem. 70(5):2070-2081, 1998.
  abstract | pdf

Sun Y, Fagan A, Wu S, Onifade K, Patel S, LaDu MJ, Bu G, and DM Holtzman. GFAP-apoE transgenic mice: Astrocyte-specific expression and differing biologic effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. J. Neurosci. 18(9):3261-3272, 1998.
  abstract | pdf

Jordan J, Galindo MF, Miller RJ, Reardon CA, Getz GS, and MJ LaDu. Isoform-specific effect of apolipoprotein E on cell survival and β-amyloid induced toxicity in rat hippocampal pyramidal neuronal cultures. J. Neurosci. 18(1):195-204, 1998.
  abstract | pdf

LaDu MJ, Lukens JR, Reardon CA, and GS Getz. Association of human, rat, and rabbit apolipoprotein E with β-amyloid. J. Neurosci. Res. 49(1):9-18, 1997.
  abstract | pdf

Puttfarcken PS, Manelli AM, Falduto MT, Getz GS and MJ LaDu. Effects of apolipoprotein E on neurite outgrowth and β-amyloid induced toxicity in developing rat primary hippocampal cultures. J. Neurochem. 68(2):760-769, 1997.
  abstract | pdf

Metzger RE, LaDu MJ, Frail DE, Pan JB, Getz GS, and MT Falduto. Neurons of the human frontal cortex display apolipoprotein E immunoreactivity: Implications for Alzheimer's disease. J. Neuropath. Exp. Neurol. 55:372-380, 1996.
  abstract | pdf

LaDu MJ, Pederson TM, Frail DE, Reardon CA, Getz GS, and MT Falduto. Purification of apolipoprotein E attenuates isoform-specific binding to β-amyloid. J. Biol. Chem. 270:9039-9042, 1995.
  abstract | pdf

LaDu MJ, Falduto MT, Manelli AM, Reardon CA, Getz GS, and DE Frail. Isoform-specific binding of apolipoprotein E to β-amyloid. J. Biol. Chem. 269:23403-23406, 1994.
  abstract | pdf